CRTC1

Across TCGA patient cohorts, CRTC1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRTC1-associated genes across cancer lineages are p62 Lck ligand, PI3K-p85, and C-Raf. Each is linked with CRTC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRTC1-to-partner and partner-to-CRTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CRTC1-low versus CRTC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTC1→partner) and Y-score (partner→CRTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.366	+2.916	.003	<.001	3	2
UCEC	PI3K-p85 →	+0.186	+2.584	.020	.010	3	2
UCEC	C-Raf →	+0.170	+1.807	.001	.025	3	2
UCEC	ERK2 →	+0.149	+3.321	.044	.009	3	1
UCEC	Ku80 →	+0.247	+2.009	.006	.017	3	1
UCEC	MEK1 →	+0.391	+2.807	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

p62 Lck ligand by CRTC1 expression — UCEC

Explore this box plot interactively →