CRTC1

Across TCGA cell cohorts, CRTC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,276 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CRTC1-associated GO terms across cancer lineages are Negative regulation of protein localization to chromatin, Regulation of DNA-templated transcription initiation, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with CRTC1 in more than 16 cancer types. Because this analysis shows association rather than direction, both CRTC1-to-partner and partner-to-CRTC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to chromatin grouped by CRTC1-low versus CRTC1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTC1→partner) and Y-score (partner→CRTC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of protein localization to chromatin →	+0.149	+0.695	<.001	<.001	3	17
URINARY_TRACT	Regulation of DNA-templated transcription initiation →	+0.070	+0.791	<.001	.003	3	17
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.197	+1.050	<.001	<.001	3	17
STOMACH	Regulation of cell fate commitment →	+0.180	+1.631	<.001	<.001	3	16
STOMACH	Positive regulation of T-helper 17 cell lineage commitment →	+0.256	+1.821	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.219	+1.069	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,276 associations by consensus.

Negative regulation of protein localization to chromatin by CRTC1 expression — LIVER

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