CRTAC1

Across TCGA patient cohorts, CRTAC1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRTAC1-associated genes across cancer lineages are Caspase-7-cleavedD198, CDK1, and Cyclin-B1. Each is linked with CRTAC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRTAC1-to-partner and partner-to-CRTAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CRTAC1-low versus CRTAC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTAC1→partner) and Y-score (partner→CRTAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.564	+3.178	<.001	.010	3	3
UCEC	CDK1 →	+0.095	+1.598	.048	.040	3	3
UCEC	Cyclin-B1 →	+0.579	+2.807	.001	.002	3	3
SKCM	PREX1 →	-0.388	-3.000	.022	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.149	-1.584	.005	.015	3	2
UCEC	p21 →	+0.121	+2.713	.048	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Caspase-7-cleavedD198 by CRTAC1 expression — COAD

Explore this box plot interactively →