CRTAC1

Across TCGA cell cohorts, CRTAC1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CRTAC1-associated genes across cancer lineages are VCY1B, OR56A5, and IQCF3. Each is linked with CRTAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRTAC1-to-partner and partner-to-CRTAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY1B grouped by CRTAC1-low versus CRTAC1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRTAC1→partner) and Y-score (partner→CRTAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VCY1B →	+1.590	+4.421	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.111	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.045	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.045	+4.887	<.001	.009	3	1
BLOOD_Leukemia	OR4F6 →	+0.018	+4.922	<.001	.009	3	1
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

VCY1B by CRTAC1 expression — BREAST

Explore this box plot interactively →