Across TCGA pan-cancer cohorts, CRPPA mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CRPPA data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CRPPA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CRPPA expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where CRPPA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.916	0.634	.003	61	view →
HNSC	OS	Median	IV	0.551	0.927	.001	57	view →
PDAC	DFS	Median	III,IV	0.866	0.493	.001	28	view →
LUAD	DFS	Quartile	All	0.795	0.964	.003	18	view →
GBM	DFS	Median	All	0.484	0.254	.001	15	view →
LSCC	DFS	Quartile	All	0.970	1.000	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: CRPPA tumor-vs-normal RNA expression · all CRPPA data types