Across TCGA patient cohorts, CRPPA mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRPPA-associated genes across cancer lineages are A-Raf_pS299, ERK2, and IRS1. Each is linked with CRPPA in more than 1 cancer types. Because this analysis shows association rather than direction, both CRPPA-to-partner and partner-to-CRPPA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRPPA→partner) and Y-score (partner→CRPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.117	-2.321	.020	.034	3	1
UCEC	ERK2 →	+0.205	+2.222	.012	.011	3	1
UCEC	IRS1 →	+0.273	+1.700	.001	.044	3	1
UCEC	JNK2 →	+0.187	+2.179	.027	.034	3	1
UCEC	Ku80 →	+0.258	+2.920	.010	.001	3	1
UCEC	MAPK_pT202_Y204 →	-0.517	-1.700	.009	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

CRPPA survival (RNA) · tumor vs normal (RNA) · all CRPPA data types