Across TCGA cell cohorts, CRPPA mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRPPA-associated genes across cancer lineages are KRTAP12-1, KIR2DS4, and COX6A2. Each is linked with CRPPA in more than 1 cancer types. Because this analysis shows association rather than direction, both CRPPA-to-partner and partner-to-CRPPA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRPPA→partner) and Y-score (partner→CRPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KRTAP12-1 →	+0.066	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KIR2DS4 →	+0.023	+4.807	<.001	.006	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ACER1 →	+0.111	+3.823	<.001	.006	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

CRPPA survival (RNA) · tumor vs normal (RNA) · all CRPPA data types