CRP

Across TCGA pan-cancer cohorts, CRP Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CRP data layer compared with 18 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CRP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CRP expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BRCA, COAD, and LIHC are the cancer types where CRP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.165	0.924	<.001	36	view →
COAD	DFS	Median	All	0.211	0.693	.001	15	view →
LIHC	OS	Median	All	0.119	0.704	.007	12	view →
UCEC	OS	Median	IV	0.308	0.748	.009	6	view →
SKCM	OS	Median	All	0.989	0.866	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CRP–BRCA (OS)

Open the BRCA breakdown →