CROCCP3

Across TCGA patient cohorts, CROCCP3 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CROCCP3-associated genes across cancer lineages are TSC1, GSK-3a-b_pS21_S9, and Heregulin. Each is linked with CROCCP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CROCCP3-to-partner and partner-to-CROCCP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC1 grouped by CROCCP3-low versus CROCCP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CROCCP3→partner) and Y-score (partner→CROCCP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSC1 →	-0.181	-3.130	.015	.018	3	2
UCEC	GSK-3a-b_pS21_S9 →	+0.499	+1.884	.007	.030	3	1
UCEC	Heregulin →	-0.122	-2.986	.023	.035	3	1
UCEC	MEK1 →	+0.435	+3.584	.006	.002	3	1
UCEC	Mre11 →	-0.087	-2.115	.019	.019	3	1
UCEC	MSH2 →	-0.250	-3.143	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

TSC1 by CROCCP3 expression — UCEC

Explore this box plot interactively →