Across TCGA pan-cancer cohorts, CROCC2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CROCC2’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CROCC2 RNA is repressed in tumor relative to normal tissue. In most cancer types CROCC2 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.
LUSC, LUAD, and LIHC are the cancer types where CROCC2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CROCC2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.