CRNKL1

Across TCGA patient cohorts, CRNKL1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRNKL1-associated genes across cancer lineages are p62 Lck ligand, p38-MAPK_pT180_Y182, and 14-3-3_epsilon. Each is linked with CRNKL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRNKL1-to-partner and partner-to-CRNKL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CRNKL1-low versus CRNKL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRNKL1→partner) and Y-score (partner→CRNKL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.342	+2.169	.005	.003	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.334	-2.115	.048	.017	3	2
SKCM	14-3-3_epsilon →	+0.102	+2.017	.030	.005	3	2
SKCM	Src_pY527 →	-0.432	-2.115	.009	.017	3	2
UCEC	4E-BP1 →	+0.267	+1.415	.008	.046	3	2
UCEC	Notch1 →	+0.179	+1.765	<.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

p62 Lck ligand by CRNKL1 expression — UCEC

Explore this box plot interactively →