CRLF3

Across TCGA patient cohorts, CRLF3 mutation is significantly associated with the immune_cell of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRLF3-associated genes across cancer lineages are MPP, CD8+ T-cells, and CD8+ Tcm. Each is linked with CRLF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRLF3-to-partner and partner-to-CRLF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by CRLF3-low versus CRLF3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRLF3→partner) and Y-score (partner→CRLF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MPP →	+0.032	+3.609	.005	.014	3	2
BRCA	CD8+ T-cells →	+0.044	+4.373	.046	.021	3	1
BRCA	CD8+ Tcm →	+0.086	+3.825	.005	.041	3	1
UCEC	CD8+ naive T-cells →	+0.030	+2.186	.011	.034	3	1
UCEC	Erythrocytes →	+0.029	+2.180	.007	.034	3	1
UCEC	lymphatic Endothelial cells →	-0.021	-2.419	.045	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MPP by CRLF3 expression — BLCA

Explore this box plot interactively →