Across TCGA patient cohorts, CRLF2 mutation is significantly associated with the RNA expression of many other genes, with 640 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRLF2-associated genes across cancer lineages are GMCL2, GTF2H3, and MRPS35P2. Each is linked with CRLF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRLF2-to-partner and partner-to-CRLF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRLF2→partner) and Y-score (partner→CRLF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GMCL2 →	+0.038	+2.671	.002	.002	3	2
SKCM	GTF2H3 →	+0.763	+3.478	.003	.002	3	2
SKCM	MRPS35P2 →	+0.063	+4.163	<.001	.006	3	2
SKCM	KRT8P3 →	+0.278	+3.529	<.001	.002	3	2
SKCM	GAN →	+0.566	+3.331	.001	.005	3	2
UCEC	AK6P1 →	+0.249	+2.397	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 640 associations by consensus.

Exploration

CRLF2 survival (RNA) · tumor vs normal (RNA) · all CRLF2 data types