CRLF2

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, CRLF2 protein abundance is significantly associated with the go_rna of many other GO terms, with 565 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRLF2-associated GO terms across cancer lineages are Somatic cell DNA recombination, Somatic diversification of immune receptors via germline recombination within a single locus, and Regulation of hydrogen peroxide catabolic process. Each is linked with CRLF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRLF2-to-partner and partner-to-CRLF2 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRLF2→partner) and Y-score (partner→CRLF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OESOPHAGUSSomatic cell DNA recombination →-0.126-1.125<.001.00833
OESOPHAGUSSomatic diversification of immune receptors via germline recombination within a single locus →-0.126-1.125<.001.00833
LARGE_INTESTINERegulation of hydrogen peroxide catabolic process →+0.290+1.179<.001.00133
SKINPre-B cell differentiation →+0.199+1.169.008.00133
SOFT_TISSUENeuronal ion channel clustering →+0.228+1.710<.001.00233
LUNG_NSCLC_LUADPositive regulation of calcium ion import across plasma membrane →+0.152+1.015<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 565 associations by consensus.

Exploration