CRLF1

Across TCGA pan-cancer cohorts, CRLF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CRLF1 data layer compared with 18 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CRLF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CRLF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, UCEC, and HNSC are the cancer types where CRLF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	1.000	0.498	.017	9	view →
UCEC	DFS	Median	All	0.663	1.000	.044	8	view →
HNSC	DFS	Median	III,IV	0.861	0.644	.029	2	view →
LSCC	OS	Tertile	All	1.000	0.833	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CRLF1–LUAD (DFS)

Open the LUAD breakdown →