CRLF1

Across TCGA patient cohorts, CRLF1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,053 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CRLF1-associated genes across cancer lineages are RHOBTB2, CORO2B, and TNS2. Each is linked with CRLF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRLF1-to-partner and partner-to-CRLF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CRLF1 versus RHOBTB2 in LUAD, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRLF1→partner) and Y-score (partner→CRLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RHOBTB2 →	+0.901	+1.060	<.001	.001	3	3
HNSC	CORO2B →	+0.702	+0.767	.001	.001	3	2
HNSC	TNS2 →	+0.991	+0.851	<.001	.002	3	2
LSCC	SOBP →	+0.675	+0.790	.003	.001	3	2
HNSC	ADAMTS7 →	+0.879	+0.831	<.001	<.001	3	2
LSCC	DAAM2 →	+0.750	+1.032	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,053 associations by consensus.

CRLF1 vs RHOBTB2 — LUAD

Explore this scatter interactively →