CRLF1

Across TCGA patient cohorts, CRLF1 mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CRLF1-associated genes across cancer lineages are RNU2-58P, RNA5SP394, and RNU6-1084P. Each is linked with CRLF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRLF1-to-partner and partner-to-CRLF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-58P grouped by CRLF1-low versus CRLF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRLF1→partner) and Y-score (partner→CRLF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU2-58P →	+0.251	+2.851	<.001	.007	3	2
UCEC	RNA5SP394 →	+0.376	+4.453	<.001	.006	3	2
SKCM	RNU6-1084P →	+0.169	+4.212	<.001	.007	3	2
SKCM	IGHD3-10 →	+1.804	+3.165	<.001	.003	3	2
SKCM	HMGB3P31 →	+0.153	+2.872	<.001	.006	3	2
BLCA	MAGI2-AS2 →	+0.072	+5.018	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

RNU2-58P by CRLF1 expression — SKCM

Explore this box plot interactively →