CRK

Across TCGA pan-cancer cohorts, CRK Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CRK data layer compared with 28 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CRK Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CRK expression acts as an unfavorable survival marker.

CESC, PRAD, and SKCM are the cancer types where CRK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.193	0.705	.045	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	All	0.127	0.324	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CRK–CESC (DFS)

Open the CESC breakdown →