CRK

Across TCGA pan-cancer cohorts, CRK mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CRK data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CRK mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CRK expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where CRK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	IV	0.861	0.131	.001	43	view →
LUAD	DFS	Quartile	All	1.000	0.456	.015	12	view →
PDAC	DFS	Quartile	II,III,IV	0.457	0.277	.018	7	view →
GBM	DFS	Quartile	All	0.176	0.423	.039	2	view →
UCEC	DFS	Median	All	0.950	0.853	.023	2	view →
LSCC	OS	Tertile	II,III,IV	0.775	1.000	.033	2	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CRK–CCRCC (DFS)

Open the CCRCC breakdown →