CRK

Across TCGA patient cohorts, CRK mutation is significantly associated with the RNA expression of many other genes, with 1,277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRK-associated genes across cancer lineages are MTND5P27, POLR2KP2, and NFILZ. Each is linked with CRK in more than 1 cancer types. Because this analysis shows association rather than direction, both CRK-to-partner and partner-to-CRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND5P27 grouped by CRK-low versus CRK-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRK→partner) and Y-score (partner→CRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTND5P27 →	+0.019	+5.209	<.001	<.001	3	2
UCEC	POLR2KP2 →	+0.218	+2.966	<.001	.002	3	2
BLCA	NFILZ →	+0.162	+5.411	<.001	.005	3	2
SKCM	CUL1P1 →	+0.028	+3.216	<.001	.005	3	1
SKCM	RNU6-581P →	+0.187	+5.906	<.001	<.001	3	1
SKCM	RNU6-1308P →	+0.161	+4.475	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,277 associations by consensus.

MTND5P27 by CRK expression — SKCM

Explore this box plot interactively →