CRK

Across TCGA patient cohorts, CRK mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRK-associated genes across cancer lineages are MYH11 and STAT3_pY705. Each is linked with CRK in more than 1 cancer types. Because this analysis shows association rather than direction, both CRK-to-partner and partner-to-CRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by CRK-low versus CRK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRK→partner) and Y-score (partner→CRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYH11 →	+1.185	+2.321	.040	.035	3	1
UCEC	STAT3_pY705 →	-0.335	-3.159	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

MYH11 by CRK expression — UCEC

Explore this box plot interactively →