CRK

Across TCGA cell cohorts, CRK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,747 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRK-associated GO terms across cancer lineages are Negative regulation of telomere capping, Positive regulation of pinocytosis, and Cytosolic ciliogenesis. Each is linked with CRK in more than 11 cancer types. Because this analysis shows association rather than direction, both CRK-to-partner and partner-to-CRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of telomere capping grouped by CRK-low versus CRK-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRK→partner) and Y-score (partner→CRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of telomere capping →	+0.127	+0.773	<.001	.001	3	12
STOMACH	Positive regulation of pinocytosis →	+0.160	+0.995	.001	<.001	3	12
LUNG_NSCLC_LUSC	Cytosolic ciliogenesis →	+0.172	+0.928	<.001	<.001	3	12
OESOPHAGUS	Response to yeast →	+0.237	+0.849	<.001	.001	3	11
LUNG_NSCLC_LUSC	Regulation of hippo signaling →	+0.094	+0.772	.006	.002	3	11
LUNG_NSCLC_LUSC	Negative regulation of hippo signaling →	+0.082	+0.522	.001	.002	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,747 associations by consensus.

Negative regulation of telomere capping by CRK expression — OVARY

Explore this box plot interactively →