CRISPLD2

Across TCGA patient cohorts, CRISPLD2 mutation is significantly associated with the RNA expression of many other genes, with 2,630 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRISPLD2-associated genes across cancer lineages are RNU6-197P, RN7SKP60, and MIR8053. Each is linked with CRISPLD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRISPLD2-to-partner and partner-to-CRISPLD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-197P grouped by CRISPLD2-low versus CRISPLD2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISPLD2→partner) and Y-score (partner→CRISPLD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-197P →	+0.407	+4.704	<.001	.005	3	2
BLCA	RN7SKP60 →	+0.140	+4.433	<.001	.007	3	2
CESC	MIR8053 →	+0.300	+4.757	<.001	.004	3	2
COAD	ACTBP6 →	+0.225	+3.911	<.001	.004	3	2
UCEC	RRM1 →	+0.806	+3.108	<.001	<.001	3	2
SKCM	CENPBD1 →	+0.681	+3.465	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,630 associations by consensus.

RNU6-197P by CRISPLD2 expression — BLCA

Explore this box plot interactively →