CRISPLD2

Across TCGA cell cohorts, CRISPLD2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CRISPLD2-associated genes across cancer lineages are H2BC1, H2AC1, and KRTAP10-1. Each is linked with CRISPLD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRISPLD2-to-partner and partner-to-CRISPLD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by CRISPLD2-low versus CRISPLD2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISPLD2→partner) and Y-score (partner→CRISPLD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1
LARGE_INTESTINE	OR51D1 →	+0.011	+3.632	<.001	.003	3	1
LARGE_INTESTINE	LMOD2 →	+0.136	+3.643	.003	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

H2BC1 by CRISPLD2 expression — SOFT_TISSUE

Explore this box plot interactively →