CRISPLD1

Across TCGA pan-cancer cohorts, CRISPLD1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CRISPLD1 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CRISPLD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CRISPLD1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where CRISPLD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.623	0.912	.007	15	view →
PDAC	DFS	Quartile	All	1.000	0.536	.024	6	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.810	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CRISPLD1–LSCC (DFS)

Open the LSCC breakdown →