CRISPLD1

Across TCGA patient cohorts, CRISPLD1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRISPLD1-associated genes across cancer lineages are FOXO3a_pS318_S321, eIF4E, and JNK_pT183_Y185. Each is linked with CRISPLD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRISPLD1-to-partner and partner-to-CRISPLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by CRISPLD1-low versus CRISPLD1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISPLD1→partner) and Y-score (partner→CRISPLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FOXO3a_pS318_S321 →	-0.120	-3.000	.040	.036	3	2
UCEC	eIF4E →	+0.158	+1.887	.027	.029	3	2
UCEC	JNK_pT183_Y185 →	-0.163	-2.321	.004	.005	3	2
UCEC	MEK1 →	+0.358	+1.807	.004	.004	3	2
UCEC	VHL →	-0.812	-1.807	<.001	.004	3	2
UCEC	ATM →	-0.463	-2.571	.002	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FOXO3a_pS318_S321 by CRISPLD1 expression — LUAD

Explore this box plot interactively →