CRISP2

Across TCGA patient cohorts, CRISP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,098 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CRISP2-associated GO terms across cancer lineages are Negative regulation of response to endoplasmic reticulum stress, Positive regulation of amide metabolic process, and Retrograde transport, endosome to Golgi. Each is linked with CRISP2 in more than 14 cancer types. Because this analysis shows association rather than direction, both CRISP2-to-partner and partner-to-CRISP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to endoplasmic reticulum stress grouped by CRISP2-low versus CRISP2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISP2→partner) and Y-score (partner→CRISP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Negative regulation of response to endoplasmic reticulum stress →	+0.062	+0.469	<.001	.003	2	15
STAD	Positive regulation of amide metabolic process →	+0.052	+0.391	<.001	<.001	3	14
STAD	Retrograde transport, endosome to Golgi →	+0.063	+0.310	<.001	.001	3	14
STAD	Cellular respiration →	+0.086	+0.433	<.001	<.001	3	14
ESCA	Organelle disassembly →	+0.056	+0.338	<.001	.002	3	13
STAD	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.055	+0.308	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,098 associations by consensus.

Negative regulation of response to endoplasmic reticulum stress by CRISP2 expression — ESCA

Explore this box plot interactively →