CRISP2

Across TCGA patient cohorts, CRISP2 mutation is significantly associated with the RNA expression of many other genes, with 890 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRISP2-associated genes across cancer lineages are RFC2, FEN1, and LMNB2. Each is linked with CRISP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRISP2-to-partner and partner-to-CRISP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFC2 grouped by CRISP2-low versus CRISP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISP2→partner) and Y-score (partner→CRISP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFC2 →	+0.611	+3.502	.002	.002	3	3
UCEC	FEN1 →	+0.855	+3.491	.001	.002	3	3
UCEC	LMNB2 →	+0.853	+3.467	.001	.002	3	3
SKCM	PDRG1 →	+0.307	+1.671	.002	.003	3	3
SKCM	FOXM1 →	+0.515	+2.141	.006	.009	3	3
UCEC	RAP2CP1 →	+0.659	+3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 890 associations by consensus.

RFC2 by CRISP2 expression — UCEC

Explore this box plot interactively →