CRISP2

Across TCGA cell cohorts, CRISP2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRISP2-associated genes across cancer lineages are MYOD1, EDDM3B, and NPY2R. Each is linked with CRISP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRISP2-to-partner and partner-to-CRISP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYOD1 grouped by CRISP2-low versus CRISP2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRISP2→partner) and Y-score (partner→CRISP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYOD1 →	+0.025	+4.922	<.001	.009	3	1
BLOOD_Leukemia	EDDM3B →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	NPY2R →	+0.126	+5.539	<.001	.003	3	1
BLOOD_Leukemia	C3orf85 →	+0.025	+5.539	.004	.003	3	1
LUNG_NSCLC_LUAD	ASB15 →	+0.044	+5.070	<.001	.001	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MYOD1 by CRISP2 expression — BLOOD_Leukemia

Explore this box plot interactively →