CRIPT

Across TCGA pan-cancer cohorts, CRIPT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CRIPT data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CRIPT mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CRIPT expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where CRIPT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.722	0.888	<.001	63	view →
LSCC	DFS	Median	All	0.980	0.898	.019	20	view →
CCRCC	OS	Median	All	0.681	1.000	.010	4	view →
GBM	OS	Median	All	0.465	0.292	.018	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CRIPT–HNSC (OS)

Open the HNSC breakdown →