CRIPT

Across TCGA patient cohorts, CRIPT protein abundance is significantly associated with the RNA expression of many other genes, with 14,290 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CRIPT-associated genes across cancer lineages are TFDP2, ZNF740, and UCK2. Each is linked with CRIPT in more than 5 cancer types. Because this analysis shows association rather than direction, both CRIPT-to-partner and partner-to-CRIPT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CRIPT versus TFDP2 in HNSC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRIPT→partner) and Y-score (partner→CRIPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TFDP2 →	+0.725	+0.409	.001	<.001	3	6
UCEC	ZNF740 →	+0.527	+0.260	<.001	<.001	3	6
UCEC	UCK2 →	+0.999	+0.320	<.001	.004	3	6
LSCC	CCDC138 →	+0.612	+0.337	<.001	<.001	3	6
HNSC	CAPN10-DT →	+0.454	+0.307	<.001	<.001	3	6
UCEC	EXOSC5 →	+1.046	+0.258	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,290 associations by consensus.

CRIPT vs TFDP2 — HNSC

Explore this scatter interactively →