CRIPT

Across TCGA cell cohorts, CRIPT RNA expression is significantly associated with the go_rna of many other GO terms, with 2,968 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CRIPT-associated GO terms across cancer lineages are Regulation of DNA damage checkpoint, DNA replication proofreading, and Vesicle fusion with Golgi apparatus. Each is linked with CRIPT in more than 9 cancer types. Because this analysis shows association rather than direction, both CRIPT-to-partner and partner-to-CRIPT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA damage checkpoint grouped by CRIPT-low versus CRIPT-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CRIPT→partner) and Y-score (partner→CRIPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA damage checkpoint →	+0.067	+0.678	.009	.004	3	10
BONE	DNA replication proofreading →	-0.194	-0.638	<.001	.004	3	9
BONE	Vesicle fusion with Golgi apparatus →	+0.111	+0.674	.005	.004	2	10
OVARY	Regulation of postsynaptic density protein 95 clustering →	+0.144	+0.835	<.001	<.001	3	9
OVARY	Vesicle targeting, rough ER to cis-Golgi →	+0.091	+0.601	<.001	.006	3	9
OVARY	Ribosomal large subunit export from nucleus →	+0.096	+0.472	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,968 associations by consensus.

Regulation of DNA damage checkpoint by CRIPT expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →