CRIM1

Across TCGA patient cohorts, CRIM1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRIM1-associated genes across cancer lineages are PCNA, STAT3_pY705, and ERK2. Each is linked with CRIM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRIM1-to-partner and partner-to-CRIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CRIM1-low versus CRIM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRIM1→partner) and Y-score (partner→CRIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.175	+1.253	.002	.006	3	3
UCEC	STAT3_pY705 →	-0.360	-1.765	<.001	<.001	3	2
UCEC	ERK2 →	+0.190	+1.584	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.657	+2.523	<.001	<.001	3	2
UCEC	ATM →	-0.628	-1.765	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.361	+1.157	.025	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PCNA by CRIM1 expression — UCEC

Explore this box plot interactively →