CRIM1

Across TCGA cell cohorts, CRIM1 mutation is significantly associated with the RNA expression of many other genes, with 174 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRIM1-associated genes across cancer lineages are CCDC182, OR9Q2, and PSG7. Each is linked with CRIM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRIM1-to-partner and partner-to-CRIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC182 grouped by CRIM1-low versus CRIM1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRIM1→partner) and Y-score (partner→CRIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCDC182 →	+0.064	+3.700	<.001	.005	3	2
LUNG_SCLC	OR9Q2 →	+0.012	+4.058	<.001	.007	3	1
LUNG_SCLC	PSG7 →	+0.088	+4.070	<.001	.003	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP3-2 →	+0.083	+6.247	<.001	<.001	3	1
BLOOD_Leukemia	LYZL2 →	+0.025	+5.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 174 associations by consensus.

CCDC182 by CRIM1 expression — OVARY

Explore this box plot interactively →