CRHR2

Across TCGA patient cohorts, CRHR2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRHR2-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Rb_pS807_S811. Each is linked with CRHR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRHR2-to-partner and partner-to-CRHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CRHR2-low versus CRHR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRHR2→partner) and Y-score (partner→CRHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.771	-3.169	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.707	+1.604	.002	.041	3	2
SKCM	Rb_pS807_S811 →	-0.393	-2.000	.043	.031	3	1
UCEC	ER-alpha_pS118 →	-0.282	-3.169	.045	.019	3	1
UCEC	INPP4B →	-0.253	-2.584	.046	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.158	-1.807	.017	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ATM by CRHR2 expression — UCEC

Explore this box plot interactively →