CRHR1

Across TCGA pan-cancer cohorts, CRHR1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated CRHR1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CRHR1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CRHR1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

KIRC, UCS, and LIHC are the cancer types where CRHR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.133	0.805	<.001	42	view →
UCS	OS	Median	All	0.104	0.688	<.001	36	view →
LIHC	OS	Median	All	0.355	0.790	<.001	24	view →
LUSC	DFS	Median	All	0.152	0.797	<.001	18	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
STAD	DFS	Median	All	0.293	0.713	.014	3	view →
LUAD	OS	Median	All	0.662	0.814	.044	2	view →
SKCM	DFS	Median	All	0.880	0.730	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CRHR1–KIRC (OS)

Open the KIRC breakdown →