CRHR1

Across TCGA patient cohorts, CRHR1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRHR1-associated genes across cancer lineages are JNK_pT183_Y185, mTOR_pS2448, and PCNA. Each is linked with CRHR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRHR1-to-partner and partner-to-CRHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CRHR1-low versus CRHR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRHR1→partner) and Y-score (partner→CRHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.215	-2.571	.006	.011	3	2
UCEC	mTOR_pS2448 →	-0.206	-3.308	.002	.009	3	2
UCEC	PCNA →	+0.311	+2.999	.001	.035	3	2
UCEC	Cyclin-E2 →	+0.181	+3.009	.021	.019	3	2
UCEC	eIF4E →	+0.196	+2.820	.046	.035	3	1
UCEC	ER-alpha →	-0.935	-3.169	.014	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

JNK_pT183_Y185 by CRHR1 expression — UCEC

Explore this box plot interactively →