CRHR1

Across TCGA cell cohorts, CRHR1 mutation is significantly associated with the mutation status of many other genes, with 648 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRHR1-associated genes across cancer lineages are PDE1B, MIEF1, and PAK5. Each is linked with CRHR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRHR1-to-partner and partner-to-CRHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE1B grouped by CRHR1-low versus CRHR1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRHR1→partner) and Y-score (partner→CRHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PDE1B →	+5.217	+4.562	<.001	<.001	1	3
BLOOD_Leukemia	MIEF1 →	+4.285	+4.285	.001	.001	1	2
BLOOD_Leukemia	PAK5 →	+3.548	+3.845	.003	.003	1	2
BLOOD_Leukemia	ACAD10 →	+2.870	+3.347	.009	.009	1	2
CNS	STIM2 →	+4.277	+4.584	.001	.001	1	2
CNS	COL7A1 →	+3.541	+4.139	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 648 associations by consensus.

PDE1B by CRHR1 expression — OVARY

Explore this box plot interactively →