CRHBP

Across TCGA pan-cancer cohorts, CRHBP Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CRHBP data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CRHBP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CRHBP expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

HNSC, READ, and SCLC are the cancer types where CRHBP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.059	0.712	<.001	24	view →
READ	DFS	Median	All	0.084	0.845	<.001	12	view →
SCLC	OS	Median	III,IV	0.082	0.639	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUAD	OS	Median	II,III,IV	0.236	0.709	.034	3	view →
UCEC	DFS	Median	II,III,IV	0.906	0.440	.045	2	view →
COAD	DFS	Median	All	1.000	0.464	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CRHBP–HNSC (OS)

Open the HNSC breakdown →