CRHBP

Across TCGA patient cohorts, CRHBP mutation is significantly associated with the RNA expression of many other genes, with 2,206 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRHBP-associated genes across cancer lineages are RNA5SP412, FRG1HP, and GPATCH11. Each is linked with CRHBP in more than 2 cancer types. Because this analysis shows association rather than direction, both CRHBP-to-partner and partner-to-CRHBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by CRHBP-low versus CRHBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRHBP→partner) and Y-score (partner→CRHBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.655	+2.382	<.001	<.001	3	3
UCEC	FRG1HP →	+0.561	+2.032	<.001	.001	3	2
UCEC	GPATCH11 →	+0.369	+2.534	.005	<.001	3	2
UCEC	SLBP →	+0.579	+2.939	<.001	<.001	3	2
UCEC	TTLL11 →	+0.318	+2.828	.006	.001	3	2
HNSC	RNU6-1052P →	+0.288	+7.954	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,206 associations by consensus.

RNA5SP412 by CRHBP expression — UCEC

Explore this box plot interactively →