CRHBP

Across TCGA patient cohorts, CRHBP mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRHBP-associated genes across cancer lineages are EGFR_pY1068, Ku80, and MEK1. Each is linked with CRHBP in more than 1 cancer types. Because this analysis shows association rather than direction, both CRHBP-to-partner and partner-to-CRHBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CRHBP-low versus CRHBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRHBP→partner) and Y-score (partner→CRHBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.199	-1.678	.039	.023	3	2
UCEC	Ku80 →	+0.211	+1.594	.020	.042	3	1
UCEC	MEK1 →	+0.422	+2.584	.002	.001	3	1
UCEC	mTOR_pS2448 →	-0.119	-1.980	.037	.030	3	1
UCEC	Notch1 →	+0.201	+2.817	<.001	.001	3	1
UCEC	p62 Lck ligand →	+0.259	+2.321	.038	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by CRHBP expression — UCEC

Explore this box plot interactively →