Across TCGA patient cohorts, CRELD2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRELD2-associated genes across cancer lineages are Rictor_pT1135, c-Kit, and 14-3-3_beta. Each is linked with CRELD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRELD2-to-partner and partner-to-CRELD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRELD2→partner) and Y-score (partner→CRELD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.101	-2.321	.010	.034	3	2
UCEC	c-Kit →	-0.194	-1.678	.030	.023	3	2
UCEC	14-3-3_beta →	-0.099	-1.664	.009	.023	3	1
UCEC	EGFR_pY1068 →	-0.240	-2.459	.012	.019	3	1
UCEC	A-Raf_pS299 →	-0.157	-2.700	<.001	.006	3	1
UCEC	ERK2 →	+0.164	+2.115	.026	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

CRELD2 survival (RNA) · tumor vs normal (RNA) · all CRELD2 data types