CRELD1

Across TCGA pan-cancer cohorts, CRELD1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CRELD1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CRELD1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CRELD1 is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

COAD, PDAC, and LSCC are the cancer types where CRELD1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRELD1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.456	<.001	8	view →
PDAC	All	II,III,IV	+0.392	<.001	6	view →
LSCC	Male	II,III,IV	−0.265	<.001	4	view →
CCRCC	All	All	−0.194	.002	2	view →
LUAD	All	All	+0.180	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CRELD1–COAD

Open the COAD breakdown →