CREG2

Across TCGA patient cohorts, CREG2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREG2-associated genes across cancer lineages are ATM, 14-3-3_beta, and A-Raf_pS299. Each is linked with CREG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREG2-to-partner and partner-to-CREG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CREG2-low versus CREG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREG2→partner) and Y-score (partner→CREG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.648	-2.115	.001	.019	3	2
UCEC	14-3-3_beta →	-0.108	-2.973	.013	.035	3	1
UCEC	A-Raf_pS299 →	-0.176	-3.169	<.001	.018	3	1
UCEC	Gab2 →	+0.317	+2.115	.042	.019	3	1
UCEC	JNK2 →	+0.305	+2.115	<.001	.019	3	1
UCEC	Ku80 →	+0.278	+2.331	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by CREG2 expression — UCEC

Explore this box plot interactively →