CREG2

Across TCGA cell cohorts, CREG2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CREG2-associated genes across cancer lineages are OR8B12, OR10V1, and HMGB4. Each is linked with CREG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREG2-to-partner and partner-to-CREG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B12 grouped by CREG2-low versus CREG2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREG2→partner) and Y-score (partner→CREG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR8B12 →	+0.094	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10V1 →	+0.046	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	HMGB4 →	+0.056	+5.539	<.001	.003	3	1
BLOOD_Leukemia	HTR3D →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.081	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP17L13 →	+0.006	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

OR8B12 by CREG2 expression — BLOOD_Leukemia

Explore this box plot interactively →