CREG1

Across TCGA patient cohorts, CREG1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREG1-associated genes across cancer lineages are JNK_pT183_Y185, Rab25, and 4E-BP1_pT37_T46. Each is linked with CREG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CREG1-to-partner and partner-to-CREG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by CREG1-low versus CREG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREG1→partner) and Y-score (partner→CREG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.221	-2.986	.023	.037	3	1
UCEC	Rab25 →	-0.537	-3.000	.005	.037	3	1
UCEC	4E-BP1_pT37_T46 →	-0.569	-3.000	.008	.037	2	2
UCEC	PCNA →	+0.259	+3.000	.038	.037	2	1
UCEC	Tuberin →	+0.407	+3.000	.009	.037	2	1
UCEC	PKC-b-II_pS660 →	-0.403	-3.000	.011	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK_pT183_Y185 by CREG1 expression — UCEC

Explore this box plot interactively →