CREBBP

Across TCGA pan-cancer cohorts, CREBBP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CREBBP data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CREBBP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CREBBP expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, HNSC, and UCEC are the cancer types where CREBBP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.877	0.518	<.001	44	view →
HNSC	DFS	Quartile	III,IV	0.858	1.000	.011	33	view →
UCEC	DFS	Median	III,IV	0.424	1.000	.003	32	view →
LUAD	DFS	Quartile	II,III,IV	1.000	0.285	.010	14	view →
GBM	OS	Quartile	All	0.719	0.243	.003	12	view →
PDAC	DFS	Median	III,IV	0.871	0.519	.005	9	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CREBBP–LSCC (DFS)

Open the LSCC breakdown →