CREBBP

Across TCGA cell cohorts, CREBBP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,808 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CREBBP-associated GO terms across cancer lineages are Regulation of nucleotide-excision repair, Epigenetic regulation of gene expression, and Regulation of cellular response to heat. Each is linked with CREBBP in more than 19 cancer types. Because this analysis shows association rather than direction, both CREBBP-to-partner and partner-to-CREBBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nucleotide-excision repair grouped by CREBBP-low versus CREBBP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CREBBP→partner) and Y-score (partner→CREBBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of nucleotide-excision repair →	+0.128	+1.206	.001	<.001	3	20
BONE	Epigenetic regulation of gene expression →	+0.095	+1.255	<.001	<.001	3	20
BONE	Regulation of cellular response to heat →	+0.138	+1.294	<.001	<.001	3	19
BONE	CAMP/PKA signal transduction →	+0.238	+1.120	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.092	+1.393	<.001	<.001	3	18
STOMACH	Symbiont-mediated disruption of host cell PML body →	+0.124	+1.511	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,808 associations by consensus.

Regulation of nucleotide-excision repair by CREBBP expression — BONE

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