CREBBP

Across TCGA cell cohorts, CREBBP mutation is significantly associated with the RNA expression of many other genes, with 1,787 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CREBBP-associated genes across cancer lineages are ZNF232, DDHD2, and HACE1. Each is linked with CREBBP in more than 3 cancer types. Because this analysis shows association rather than direction, both CREBBP-to-partner and partner-to-CREBBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF232 grouped by CREBBP-low versus CREBBP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREBBP→partner) and Y-score (partner→CREBBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF232 →	+0.727	+2.672	<.001	<.001	3	4
BLOOD_Lymphoma	DDHD2 →	+0.629	+2.459	.001	.005	3	4
LARGE_INTESTINE	HACE1 →	+0.738	+1.891	<.001	<.001	3	4
LARGE_INTESTINE	CRACD →	+0.944	+2.541	<.001	.001	3	3
OVARY	NPRL2 →	+0.509	+2.459	.001	.009	3	3
OVARY	WRAP53 →	+0.664	+2.459	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,787 associations by consensus.

ZNF232 by CREBBP expression — LARGE_INTESTINE

Explore this box plot interactively →