CREB5

Across TCGA patient cohorts, CREB5 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CREB5-associated genes across cancer lineages are Cyclin-B1, A-Raf_pS299, and MSH2. Each is linked with CREB5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CREB5-to-partner and partner-to-CREB5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CREB5-low versus CREB5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CREB5→partner) and Y-score (partner→CREB5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.673	+2.169	<.001	<.001	3	3
UCEC	A-Raf_pS299 →	-0.126	-1.999	<.001	.002	3	2
UCEC	MSH2 →	-0.276	-1.973	<.001	.008	3	2
UCEC	TFRC →	+0.338	+1.201	.040	.028	3	2
UCEC	Caspase-7-cleavedD198 →	+0.690	+1.893	<.001	<.001	3	2
UCEC	c-Met →	-0.210	-1.893	.023	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Cyclin-B1 by CREB5 expression — UCEC

Explore this box plot interactively →